Half Life

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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. We comply with the HONcode standard for trustworthy health information - verify here. Skip to Content. What do you mean by the half life of a drug? Official Answer by Drugs. For example: The half-life of Ambien is about 2 hours. Recently Approved.

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FDA alerts. Daily news summary. Weekly news roundup. The smaller the value of k s , the higher the affinity binding of drug to its target ligand, which is an important aspect of drug design.

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Define the following term: therapeutic range, half-life, zero order reaction, first order reaction, second order reaction. The patient forgot to take the drug at the end of the dosage interval, he decided to take double the amount of drug B at the end of the next dosage interval. Will the drug still be in its therapeutic range? A patient is treating with 32P.

The half-life of the material is 15 days. Therapeutic range: the range that is between maximum drug concentration and a minimum drug concentration in which it is capable of fully exhibit its effective activity. Zero order reaction , First order reaction , Second order reaction : see module to understand its definition.

The dosage interval is the half-life of the drug, looking at the graph, the half-life is 10 hours.

Half-life and carbon dating

The best way to determine rate constant k in half-life of first order is to determine half-life by experimental data. The reason is half-life in first order order doesnt depend on initial concentration. Zero order kinetics In zero-order kinetics, the rate of a reaction does not depend on the substrate concentration. First Order Kinetics In First order reactions , the graph represents the half-life is different from zero order reaction in a way that the slope continually decreases as time progresses until it reaches zero.


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Second Order Reactions Half-life of second order reactions shows concentration [A] vs. Example 1: Pharmacokinetics A following example is given below to illustrate the role of half life in pharmacokinetics to determine the drugs dosage interval. Problems 1. Examine the following graph and answer What is the therapeutic range of drug B?

A precious decay

From the graph, estimate the dosage interval of drug B to ensure its maximum effect? In first order half life, what is the best way to determine the rate constant k? The half-life is 10 days.

The Discovery of Half-Lives

Determine its rate constant k? Solutions 1. Therapeutic range: the range that is between maximum drug concentration and a minimum drug concentration in which it is capable of fully exhibit its effective activity Half-life: the amount of time it required for a reaction to undergoing decay by half.

RLO: Pharmacology: Half-life of Drugs

Zero order reaction , First order reaction , Second order reaction : see module to understand its definition 2. Even though it will get in the therapeutic range, such practice is not recommended.

References Chang, Raymond. Physical Chemistry for the Biosciences.